Defect in retinal computation linked to congenital nystagmus
A clearly defined neuron type has been identified, along with its circuit in the retina in the pathophysiology of idiopathic congenital nystagmus. In a mouse model of the disease, which shows similar clinical symptoms as patients, a defect in starburst cells elicited by dysfunctional FRMD7 leads to the loss of the horizontal optokinetic reflex.
